Quantitative Estimation of Insulin Sensitivity in Type 1 Diabetic Subjects Wearing a Sensor-Augmented Insulin Pump

• Published in: Diabetes care Vol. 37; no. 5; pp. 1216 - 1223
• Main Authors: Schiavon, Michele, Dalla Man, Chiara, Kudva, Yogish C., Basu, Ananda, Cobelli, Claudio
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 2014
• Subjects: Adult; Advances in Artificial Pancreas Development; Biological and medical sciences; Blood Glucose - metabolism; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glucose; Glycemic index; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - therapeutic use; Insulin; Insulin - administration & dosage; Insulin - blood; Insulin - therapeutic use; Insulin Infusion Systems; Insulin Resistance - physiology; Male; Mathematics; Meals; Medical sciences; Metabolic diseases; Middle Aged; Monitoring systems; Reproducibility of Results; Time Factors; Treatment Outcome; Endocrinopathy; Human; Immunopathology; Pancreatic hormone; Nutrition; Insulin sensitivity; Estimation; Measurement sensor; Autoimmune disease; Metabolic diseases; Insulin; Type 1 diabetes; Insulin pump; Endocrinology; Quantitative analysis
• ISSN: 0149-5992; 1935-5548; 1935-5548
• DOI: 10.2337/dc13-1120

The goal was to develop a new index of insulin sensitivity in patients with type 1 diabetes estimated from continuous glucose monitoring (CGM) and subcutaneous insulin delivery data under carefully controlled conditions. The database consists of 12 subjects with type 1 diabetes, studied during break...