Efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infection in children: a multicenter, randomized, double-blind, placebo-controlled trial

• Published in: BMC pulmonary medicine Vol. 25; no. 1; pp. 382 - 9
• Main Authors: Xu, Baoping, Han, Peng, Shang, Yunxiao, Cheng, Huanji, Han, Zhiying, Zhao, Lin, He, Shaoru, Lu, Min, Liu, Enmei, Shen, Kunling
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.08.2025; BMC
• Subjects: Administration, Inhalation; Ambroxol; Ambroxol - administration & dosage; Ambroxol - adverse effects; Ambroxol - therapeutic use; Analysis; Antitussive agents; Child; Child, Preschool; Children; Dosage and administration; Double-Blind Method; Drug therapy; Expectorants - administration & dosage; Expectorants - adverse effects; Expectorants - therapeutic use; Female; Health aspects; Humans; Infant; Inhalers; Lower respiratory tract infections; Male; Patient outcomes; Physiology, Pathological; Respiratory tract infections; Respiratory Tract Infections - drug therapy; Sputum; Sputum - drug effects; Treatment Outcome; China; Lower respiratory tract infections; Ambroxol; Children; Sputum

To evaluate the efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infections (LRTIs) in children. This study was a randomized, double-blind, parallel-group, placebo-controlled, multicenter trial. The patients were administered inhaled ambroxol or a place...