Pharmacokinetics, Pharmacodynamics, and Safety of Single Dose HSK7653 Tablets in Chinese Subjects with Normal or Impaired Renal Function

• Published in: Clinical pharmacokinetics Vol. 63; no. 2; pp. 227 - 239
• Main Authors: Shi, Dan, Chen, Lin, Li, Gexuan, Wu, Nan, Zhang, Fengyi, Wang, Xiaofei, Mu, Nan, Chen, Xi, Yang, Xiangyi, Lu, Jia, Lu, Yali, Wang, Meixia, Zhang, Dongliang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2024
• Subjects: Internal Medicine; Medicine; Medicine & Public Health; NCT; NCT05497297; Original Research Article; Pharmacology/Toxicology; Pharmacotherapy

Objective HSK7653 is a novel, ultralong-acting dipeptidyl peptidase-4 (DPP-4) inhibitor, promising for type 2 diabetes mellitus with a dosing regimen of once every 2 weeks. This trial investigates the pharmacokinetics (PKs), pharmacodynamics (PDs),and safety of HSK7653 in outpatients with normal or...