Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis

• Published in: Journal of cardiovascular translational research Vol. 14; no. 6; pp. 1051 - 1062
• Main Authors: Zeng, Ni, Wen, Yi-Hong, Pan, Rong, Yang, Jing, Yan, Yu-Min, Zhao, An-Zhi, Zhu, Jie-Ning, Fang, Xian-Hong, Shan, Zhi-Xin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2021
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Angiotensin II - pharmacology; Animals; Biomedical Engineering and Bioengineering; Biomedicine; Cardiology; Cardiomyopathies - genetics; Female; Fibrosis - genetics; Gene Expression; Human Genetics; Male; Medicine; Medicine & Public Health; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; Original Article; Smad3 Protein - genetics; miR-25-3p; Cardiac fibroblasts; Myocardial fibrosis; Smad3; Dkk3

Increasing evidence has shown that microRNAs (miRNAs) participate in cardiac fibrosis. We aimed to elucidate the effect of miRNA miR-25-3p on cardiac fibrosis. MiRNA microarray was used to profile miRNAs in the myocardium of angiotensin-II (Ang-II)-infused mice. Effect of miR-25-3p on expression of...