Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy - Yoshida, Keisuke; Yamaguchi, Kazuya; Mizuno, Akira; Unno, Yuka; Asai, Akira; Sone, Takayuki; Yokosawa, Hideyoshi; Matsuda, Akira; Arisawa, Mitsuhiro; Shuto, Satoshi (Organic & biomolecular chemistry, 2009)
Keywords: Cell Survival - drug effects; Chemistry; Chemistry, Organic; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; HeLa Cells; Humans; Isomerism; Models, Molecular; Molecular Structure; Peptides - chemical synthesis; Peptides - chemistry; Peptides - pharmacology; Physical Sciences; Proteasome Inhibitors; Science & Technology; Stereoisomerism; Structure-Activity Relationship; TARGET; CONFORMATIONAL RESTRICTION; ASYMMETRIC-SYNTHESIS; DRUG DEVELOPMENT; CYCLOPROPANATION; CELL-CYCLE; STEREOSELECTIVE-SYNTHESIS; PROTEOLYSIS; HISTAMINE; NF-KAPPA-B