Palladium catalyzed C–C and C–N bond forming reactions: an update on the synthesis of pharmaceuticals from 2015–2020

• Published in: Organic chemistry frontiers an international journal of organic chemistry Vol. 8; no. 2; pp. 384 - 414
• Main Authors: Jayachandra Rayadurgam, Sravani Sana, Sasikumar, M, Gu, Qiong
• Format: Journal Article
• Language: English
• Published: London Royal Society of Chemistry 26.01.2021
• Subjects: Carbon; Catalysts; Chemical reactions; Chemical synthesis; Coupling (molecular); Cross coupling; Drugs; FDA approval; Intermediates; Nitrogen; Organic chemistry; Palladium; Pharmaceutical industry; Pharmaceutical sciences; Pharmaceuticals; United States > US

Some of the most prominent and promising catalysts in organic synthesis for the requisite construction of C–C and C–N bonds are palladium (Pd) catalysts, which play a pivotal role in pharmaceutical and medicinal chemistry. Their wide range of selectivities, mild reaction conditions, and simple, effi...