Evidence for upregulation of excitatory synaptic transmission in the substantia nigra in Schizophrenia: a postmortem ultrastructural study

• Published in: Journal of Neural Transmission Vol. 130; no. 4; pp. 561 - 573
• Main Authors: Brown, Nicole K., Roche, Joy K., Farmer, Charlene B., Roberts, Rosalinda C.
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.04.2023
• Subjects: Dopamine; Humans; Medicine; Medicine & Public Health; Neurology; Neurosciences; Psychiatry; Psychiatry and Preclinical Psychiatric Studies - Original Article; Schizophrenia; Substantia Nigra - metabolism; Synaptic Transmission; Up-Regulation; Psychosis; Dopamine; Postsynaptic density; Glutamate; Ultrastructure

The dopamine hypothesis of schizophrenia suggests that psychotic symptoms originate from dysregulation of dopaminergic activity, which may be controlled by upstream innervation. We hypothesized that we would find anatomical evidence for the hyperexcitability seen in the SN. We examined and quantifie...