Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy

The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or centromedian (n = 2) thalamic deep brain stimulation (DBS) for epilepsy. Five patients (all AN) had > or = 50% seizure reduction, although benefit was delayed in two until years 5 to 6, after change...

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Published inNeurology Vol. 66; no. 10; p. 1571
Main Authors Andrade, D M, Zumsteg, D, Hamani, C, Hodaie, M, Sarkissian, S, Lozano, A M, Wennberg, R A
Format Journal Article
LanguageEnglish
Published United States 23.05.2006
Subjects
Adolescent
Adult
Anticonvulsants - therapeutic use
Combined Modality Therapy
Deep Brain Stimulation - adverse effects
Epilepsies, Partial - drug therapy
Epilepsies, Partial - therapy
Epilepsy - drug therapy
Epilepsy - therapy
Epilepsy, Generalized - drug therapy
Epilepsy, Generalized - therapy
Female
Follow-Up Studies
Hallucinations - etiology
Humans
Male
Middle Aged
Nystagmus, Pathologic - etiology
Single-Blind Method
Sleep Stages
Thalamus
Treatment Failure
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Summary:The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or centromedian (n = 2) thalamic deep brain stimulation (DBS) for epilepsy. Five patients (all AN) had > or = 50% seizure reduction, although benefit was delayed in two until years 5 to 6, after changes in antiepileptic drugs. DBS electrode implantation in AN patients was followed by seizure reduction 1 to 3 months before active stimulation, raising the possibility of a beneficial microthalamotomy effect.
ISSN:1526-632X
DOI:10.1212/01.wnl.0000206364.19772.39