Efficacy of very-low-dose oral food challenge in children with severe hen egg allergy: A retrospective, single-center case series

• Published in: Allergology international Vol. 73; no. 4; pp. 543 - 549
• Main Authors: Yamashita, Kosei, Mayu, Maeda, Imai, Takanori, Takagi, Toshiyuki, Okawa, Megumi, Honda, Aiko, Kunigami, Chihiro, Okada, Yuki, Kamiya, Taro
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.10.2024; Elsevier
• Subjects: Administration, Oral; Allergens - administration & dosage; Allergens - immunology; Animals; Chickens; Child, Preschool; Egg Hypersensitivity - immunology; Eggs - adverse effects; Female; Food allergy; Hen egg; Humans; Immunoglobulin E - blood; Immunoglobulin E - immunology; Infant; Male; Management; Minimum avoidance; Oral food challenge; Retrospective Studies; Food allergy; Oral food challenge; EAACI; sIgE; AD; IgE; OVM; ITT; Minimum avoidance; Management; OFC; Hen egg; VLD; SPT; LD; ESI; OIT; HE; BSACI

To avoid complete elimination of hen eggs (HE) from diet, we introduced a very-low-dose (VLD) oral food challenge (OFC) in patients with severe HE allergy in 2019. Herein, we investigated the efficacy of VLD HE OFC for achieving the full dose OFC. Patients with an overt allergic reaction to LD (1/32...