Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers

• Published in: Neurology Vol. 64; no. 5; p. 792
• Main Authors: Salinsky, M C, Storzbach, D, Spencer, D C, Oken, B S, Landry, T, Dodrill, C B
• Format: Journal Article
• Language: English
• Published: United States 08.03.2005
• Subjects: Activities of Daily Living; Adult; Amines - adverse effects; Anticonvulsants - adverse effects; Brain - drug effects; Brain - physiopathology; Cognition - drug effects; Cognition - physiology; Cognition Disorders - chemically induced; Cognition Disorders - physiopathology; Cognition Disorders - psychology; Cyclohexanecarboxylic Acids - adverse effects; Dose-Response Relationship, Drug; Fructose - adverse effects; Fructose - analogs & derivatives; gamma-Aminobutyric Acid - adverse effects; Humans; Maximum Tolerated Dose; Middle Aged; Neuropsychological Tests; Patient Selection; Reference Values; Risk Factors; Treatment Outcome

To evaluate the cognitive effects of topiramate (TPM) and gabapentin (GBP). Forty healthy volunteers were randomized to a 12-week course of TPM, GBP, or placebo. Doses were gradually escalated over 10 weeks to a maximum of 400 mg/day of TPM or 3,600 mg/day of GBP or to the highest tolerated dose. Su...