Computational modeling of chromosome re-replication in mutant strains of fission yeast

• Published in: Molecular biology of the cell Vol. 32; no. 9; pp. 830 - 841
• Main Authors: Novák, Béla, Tyson, John J.
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 19.04.2021

A dynamic model is proposed for endoreplication cycles based on a limit-cycle oscillation generated by a transcriptional negative feedback loop, which is amplified by two positive feedbacks. Using phase plane techniques and bifurcation analysis, we show that the model accounts for the phenotype of v...