Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity

• Published in: Nature cancer Vol. 3; no. 6; p. 734
• Main Authors: Tsai, Kelvin K, Huang, Shenq-Shyang, Northey, Jason J, Liao, Wen-Ying, Hsu, Chung-Chi, Cheng, Li-Hsin, Werner, Michael E, Chuu, Chih-Pin, Chatterjee, Chandrima, Lakins, Jonathon N, Weaver, Valerie M
• Format: Journal Article
• Language: English
• Published: England 01.06.2022
• Subjects: Antineoplastic Agents; Breast Neoplasms - drug therapy; Cell Line, Tumor; Early Detection of Cancer; Female; Humans; Neoplasm Recurrence, Local; Nuclear Receptor Co-Repressor 2 - genetics; Organoids - metabolism; Proteomics

Resistance to antitumor treatment contributes to patient mortality. Functional proteomic screening of organoids derived from chemotherapy-treated patients with breast cancer identified nuclear receptor corepressor 2 (NCOR2) histone deacetylase as an inhibitor of cytotoxic stress response and antitum...