Modulatory role of genistein on placenta and maternal bone minerals composition: further insight into its influence on pregnancy and foetal development

s Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of altering the maternal bone mineral density when there is no balance between demand and supply of these minerals. This study evaluated the influence...

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Published inBiologia futura Vol. 71; no. 3; pp. 223 - 230
Main Authors Samuel, Titilola Aderonke, Awobajo, Funmileyi Olubajo, Akinsanya, Taiwo Hafsah, Oyediran, Habeeb Shemilore, Egege, Ikechukwu Eric, Egede, Chiamaka Blessing, Timothy, Bukola Oluwasegun
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.09.2020
Subjects
Animals
Biomedical and Life Sciences
Bone and Bones - drug effects
Bone and Bones - metabolism
Cell Biology
Ecotoxicology
Female
Fetal Development - drug effects
Genistein - pharmacology
Life Sciences
Male
Metals - metabolism
Neurobiology
Original Paper
Phytoestrogens - pharmacology
Placenta - drug effects
Placenta - metabolism
Plant Sciences
Pregnancy
Rats
Rats, Sprague-Dawley
Zoology
Pregnancy
Placenta
Zn
Arsenic
Genistein
Bone minerals
Ca
Heavy metals
Ca2
Zn2
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Abstract s Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of altering the maternal bone mineral density when there is no balance between demand and supply of these minerals. This study evaluated the influence of genistein on the maternal bone and placenta mineral composition. Pregnant rats were grouped into control, 2 mg/kg and 4 mg/kg genistein groups, dosed accordingly till sacrificed at different gestation days (GD). Body and placenta weights, right femur bone and placenta mineral composition were analysed. A significant decrease in body weight and percentage relative right femur bone weight at GD-20 was recorded in the 2-mg group with the reverse occurring in the 4-mg genistein group. The right femur bone Ca 2+ and Zn 2+ was reduced towards GD-20 in both 2-mg and 4-mg genistein groups. Genistein had no influence on placenta selenium and cadmium level, but significantly decreased zinc and lead level concentration as the gestation progressed towards GD-20. Copper level was increased at GD-16 at the doses used. Genistein modulated maternal bone mineral composition and placenta capability in retaining some heavy metals at various stages of pregnancy.
AbstractList Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of altering the maternal bone mineral density when there is no balance between demand and supply of these minerals. This study evaluated the influence of genistein on the maternal bone and placenta mineral composition. Pregnant rats were grouped into control, 2 mg/kg and 4 mg/kg genistein groups, dosed accordingly till sacrificed at different gestation days (GD). Body and placenta weights, right femur bone and placenta mineral composition were analysed. A significant decrease in body weight and percentage relative right femur bone weight at GD-20 was recorded in the 2-mg group with the reverse occurring in the 4-mg genistein group. The right femur bone Ca and Zn was reduced towards GD-20 in both 2-mg and 4-mg genistein groups. Genistein had no influence on placenta selenium and cadmium level, but significantly decreased zinc and lead level concentration as the gestation progressed towards GD-20. Copper level was increased at GD-16 at the doses used. Genistein modulated maternal bone mineral composition and placenta capability in retaining some heavy metals at various stages of pregnancy.
s Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of altering the maternal bone mineral density when there is no balance between demand and supply of these minerals. This study evaluated the influence of genistein on the maternal bone and placenta mineral composition. Pregnant rats were grouped into control, 2 mg/kg and 4 mg/kg genistein groups, dosed accordingly till sacrificed at different gestation days (GD). Body and placenta weights, right femur bone and placenta mineral composition were analysed. A significant decrease in body weight and percentage relative right femur bone weight at GD-20 was recorded in the 2-mg group with the reverse occurring in the 4-mg genistein group. The right femur bone Ca 2+ and Zn 2+ was reduced towards GD-20 in both 2-mg and 4-mg genistein groups. Genistein had no influence on placenta selenium and cadmium level, but significantly decreased zinc and lead level concentration as the gestation progressed towards GD-20. Copper level was increased at GD-16 at the doses used. Genistein modulated maternal bone mineral composition and placenta capability in retaining some heavy metals at various stages of pregnancy.
Author Awobajo, Funmileyi Olubajo
Akinsanya, Taiwo Hafsah
Oyediran, Habeeb Shemilore
Timothy, Bukola Oluwasegun
Samuel, Titilola Aderonke
Egege, Ikechukwu Eric
Egede, Chiamaka Blessing
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  surname: Timothy
  fullname: Timothy, Bukola Oluwasegun
  organization: Department of Physiology, College of Medicine, University of Lagos
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34554508$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1016_j_ygcen_2022_114122
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Issue 3
Keywords Pregnancy
Placenta
Zn
Arsenic
Genistein
Bone minerals
Ca
Heavy metals
Ca2
Zn2
Language English
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Snippet s Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of...
Pregnancy is a crucial period with an increased need to supply necessary minerals for both the mother and the developing foetus and with a tendency of altering...
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SubjectTerms Animals
Biomedical and Life Sciences
Bone and Bones - drug effects
Bone and Bones - metabolism
Cell Biology
Ecotoxicology
Female
Fetal Development - drug effects
Genistein - pharmacology
Life Sciences
Male
Metals - metabolism
Neurobiology
Original Paper
Phytoestrogens - pharmacology
Placenta - drug effects
Placenta - metabolism
Plant Sciences
Pregnancy
Rats
Rats, Sprague-Dawley
Zoology
Title Modulatory role of genistein on placenta and maternal bone minerals composition: further insight into its influence on pregnancy and foetal development
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https://www.ncbi.nlm.nih.gov/pubmed/34554508
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