Mechanistic Understanding for the Greater Sensitivity of Monkeys to Antisense Oligonucleotide–Mediated Complement Activation Compared with Humans - Shen, Lijiang; Frazer-Abel, Ashley; Reynolds, Paul R.; Giclas, Patricia C.; Chappell, Alfred; Pangburn, Michael K.; Younis, Husam; Henry, Scott P. (The Journal of pharmacology and experimental therapeutics, 2014)
Keywords: Adolescent; Adult; Amino Acid Sequence; Animals; Complement Activation - drug effects; Complement Activation - physiology; Complement Factor H - genetics; Comprehension; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Macaca fascicularis; Male; Middle Aged; Molecular Sequence Data; Oligonucleotides; Oligonucleotides, Antisense - genetics; Oligonucleotides, Antisense - pharmacology; Oligoribonucleotides - genetics; Oligoribonucleotides - pharmacology; Young Adult; RBC; PS; CFH; SNP; ULN; ASO; EOI; 2′-MOE; AP; ELISA