Cynomolgus Monkey as a Potential Model to Assess Drug Interactions Involving Hepatic Organic Anion Transporting Polypeptides: In Vitro, In Vivo, and In Vitro-to-In Vivo Extrapolation

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 344; no. 3; pp. 673 - 685
• Main Authors: Shen, Hong, Yang, Zheng, Mintier, Gabe, Han, Yong-Hae, Chen, Cliff, Balimane, Praveen, Jemal, Mohammed, Zhao, Weiping, Zhang, Renjie, Kallipatti, Sanjith, Selvam, Sabariya, Sukrutharaj, Sunil, Krishnamurthy, Prasad, Marathe, Punit, Rodrigues, A. David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2013
• Subjects: Animals; Biological Transport; Cell Line; Cloning, Molecular - methods; Drug Interactions; Fluorobenzenes - pharmacology; HEK293 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; Humans; Inhibitory Concentration 50; Liver - drug effects; Liver - metabolism; Macaca fascicularis - metabolism; Male; Models, Animal; Organic Anion Transporters - genetics; Organic Anion Transporters - metabolism; Pyrimidines - pharmacology; Rifampin - pharmacology; Rosuvastatin Calcium; Sulfonamides - pharmacology; Km; Pdiff; E3S; Iave; IVIVE; DDI; FRT; AUC; fu; Iin,max; LC-MS/MS; QC; HEK-293; CCK-8; Imax; m/z; P450; HPLC; E17βG; CI; cOATP; Vmax; hOATP; OATP; RIF; CsA; RSV; HBSS; PCR

Organic anion–transporting polypeptides (OATP) 1B1, 1B3, and 2B1 can serve as the loci of drug–drug interactions (DDIs). In the present work, the cynomolgus monkey was evaluated as a potential model for studying OATP-mediated DDIs. Three cynomolgus monkey OATPs (cOATPs), with a high degree of amino...