Cynomolgus Monkey as a Potential Model to Assess Drug Interactions Involving Hepatic Organic Anion Transporting Polypeptides: In Vitro, In Vivo, and In Vitro-to-In Vivo Extrapolation - Shen, Hong; Yang, Zheng; Mintier, Gabe; Han, Yong-Hae; Chen, Cliff; Balimane, Praveen; Jemal, Mohammed; Zhao, Weiping; Zhang, Renjie; Kallipatti, Sanjith; Selvam, Sabariya; Sukrutharaj, Sunil; et al. (The Journal of pharmacology and experimental therapeutics, 2013)
Keywords: Animals; Biological Transport; Cell Line; Cloning, Molecular - methods; Drug Interactions; Fluorobenzenes - pharmacology; HEK293 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; Humans; Inhibitory Concentration 50; Liver - drug effects; Liver - metabolism; Macaca fascicularis - metabolism; Male; Models, Animal; Organic Anion Transporters - genetics; Organic Anion Transporters - metabolism; Pyrimidines - pharmacology; Rifampin - pharmacology; Rosuvastatin Calcium; Sulfonamides - pharmacology; Km; Pdiff; E3S; Iave; IVIVE; DDI; FRT; AUC; fu; Iin,max; LC-MS/MS; QC; HEK-293; CCK-8; Imax; m/z; P450; HPLC; E17βG; CI; cOATP; Vmax; hOATP; OATP; RIF; CsA; RSV; HBSS; PCR