The regulating effect of curcumin on NF-κB pathway in neurodegenerative diseases: a review of the underlying mechanisms

• Published in: Inflammopharmacology Vol. 32; no. 4; pp. 2125 - 2151
• Main Authors: Esmaealzadeh, Niusha, Miri, Mahdis Sadat, Mavaddat, Helia, Peyrovinasab, Amirreza, Ghasemi Zargar, Sara, Sirous Kabiri, Shirin, Razavi, Seyed Mehrad, Abdolghaffari, Amir Hossein
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2024
• Subjects: Allergology; Animals; Anti-Inflammatory Agents - pharmacology; Biomedical and Life Sciences; Biomedicine; Curcumin - pharmacology; Dermatology; Gastroenterology; Humans; Immunology; Inflammation - drug therapy; Inflammation - metabolism; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; NF-kappa B - metabolism; Oxidative Stress - drug effects; Pharmacology/Toxicology; Review; Rheumatology; Signal Transduction - drug effects; Herbal medicine; Neuroinflammation; Alzheimer’s disease; Parkinson’s disease; Phytopharmacology

Neurodegenerative diseases are part of the central nervous system (CNS) disorders that indicate their presence with neuronal loss, neuroinflammation, and increased oxidative stress. Several pathophysiological factors and biomarkers are involved in this inflammatory process causing these neurological...