Light and electron microscopic observations on the relationship between Hirano bodies, neuron and glial perikarya in the human hippocampus

Hippocampi from two intellectually normal and four demented subjects were examined in autopsy material. Large Hirano bodies seen by light and electron microscopy were thought to be glial in origin and not to be produced by the perikarya of neurons as has been suggested in the literature. Myelination...

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Bibliographic Details
Published inActa neuropathologica Vol. 42; no. 3; p. 165
Main Author Gibson, P H
Format Journal Article
LanguageEnglish
Published Germany 01.01.1978
Subjects
Age Factors
Hippocampus - ultrastructure
Humans
Inclusion Bodies - ultrastructure
Microscopy, Electron
Middle Aged
Neuroglia - ultrastructure
Neurons - ultrastructure
Oligodendroglia - ultrastructure
Ribosomes - ultrastructure
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Summary:Hippocampi from two intellectually normal and four demented subjects were examined in autopsy material. Large Hirano bodies seen by light and electron microscopy were thought to be glial in origin and not to be produced by the perikarya of neurons as has been suggested in the literature. Myelination of two Hirano bodies found in the stratum lacunosum-granulosum where neuron perikarya are rare suggests that these bodies are produced by oligodendroglia. Hirano bodies were found to be associated with neurons showing granulovaculoar degeneration. With electron microscope they were frequently seen to be divided by clefts filled with amorphous material which possibly consisted of free ribosomes.
ISSN:0001-6322
DOI:10.1007/bf00690353