The efficacy and safety of trastuzumab deruxtecan (T-DXd) in HER2-expressing solid tumours: a single-arm meta-analysis

• Published in: Japanese journal of clinical oncology Vol. 53; no. 8; pp. 722 - 729
• Main Authors: Kou, Liqiu, Chen, Xiu, Xie, Xiaolu, Wen, Qinglian, Li, Jun, Li, Yaling
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 31.07.2023
• Subjects: Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Camptothecin - therapeutic use; Female; Humans; Immunoconjugates - adverse effects; Lung Neoplasms - drug therapy; Receptor, ErbB-2; Trastuzumab - adverse effects; trastuzumab deruxtecan (T-DXd); solid tumours; HER2-expressing; safety; antibody-drug couples; meta-analysis; efficacy

Abstract Objective We performed a meta-analysis to assess the efficacy and safety of T-DXd in the treatment of HER2-expressing solid tumours. Methods We systematically searched PubMed, Web of Science, Embase and the Cochrane Library and collected studies published before March 17, 2023, on T-DXd for...