Altered distribution and enhanced osteoclastogenesis of mucosal-associated invariant T cells in gouty arthritis

• Published in: Rheumatology (Oxford, England) Vol. 59; no. 8; pp. 2124 - 2134
• Main Authors: Cho, Young-Nan, Jeong, Hae-Seong, Park, Ki-Jeong, Kim, Hyung-Seok, Kim, Eun-Hee, Jin, Hye-Mi, Jung, Hyun-Ju, Ju, Jae Kyun, Choi, Sung-Eun, Kang, Ji-Hyoun, Park, Dong-Jin, Kim, Tae-Jong, Lee, Shin-Seok, Kee, Seung-Jung, Park, Yong-Wook
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2020
• Subjects: Adult; Aged; Arthritis, Gouty - metabolism; Cell Movement - physiology; Cytokines - metabolism; Female; Flow Cytometry; Humans; Hyperuricemia - metabolism; Leukocytes, Mononuclear - metabolism; Male; Middle Aged; Mucosal-Associated Invariant T Cells - metabolism; Osteogenesis - physiology; mucosal-associated invariant T cells; migration; MSU crystals; gouty arthritis; osteoclastogenesis

Abstract Objective This study was designed to investigate the role of mucosal-associated invariant T (MAIT) cells in gouty arthritis (GA) and their effects on osteoclastogenesis. Methods Patients with GA (n = 61), subjects with hyperuricaemia (n = 11) and healthy controls (n = 30) were enrolled in t...