Evaluation of indole-based organometallics as transfer hydrogenation catalysts with anticancer activity

• Published in: Journal of organometallic chemistry Vol. 1013; p. 123168
• Main Authors: Rafols, Laia, Azmanova, Maria, Perrigault, Nathan, Cooper, Patricia A., Shnyder, Steven D., Martin, William H.C., Pitto-Barry, Anaïs
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2024; Elsevier
• Subjects: Bioactive ligand; Bioorganometallic chemistry; Cancer; Catalysis in cells; Chemical Sciences; Coordination chemistry; Life Sciences; Medicinal Chemistry; Metal-based drugs; Metal-based drugs; Bioorganometallic chemistry; Catalysis in cells; Bioactive ligand

•Neutral metal complexes with a S∩N indole ligand have been synthesised.•The metal ion (Ru, Os, Rh, Ir) influences the catalytic activity for NAD+ reduction.•In vivo studies reveal Rh complex exhibits the more selectivity.•The mechanism of action is based on ROS production. Half-sandwich complexes c...