Effect of antimalarials on clinical outcomes in lupus nephritis

• Published in: Rheumatology (Oxford, England) Vol. 63; no. 8; pp. 2230 - 2238
• Main Authors: Peña-Vizcarra, Óscar R, Zavala-Miranda, María Fernanda, Juárez-Cuevas, Bernardo, Márquez-Macedo, Sofía E, Hernández-Andrade, Adriana, Nordmann-Gomes, Alberto, Pérez-Arias, Abril A, Morales-Buenrostro, Luis E, Mejía-Vilet, Juan M
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2024
• Subjects: Adult; Antimalarials - therapeutic use; Disease Progression; Female; Glomerular Filtration Rate - drug effects; Humans; Hydroxychloroquine - therapeutic use; Incidence; Lupus Nephritis - drug therapy; Male; Retrospective Studies; Symptom Flare Up; Treatment Outcome; Young Adult; chloroquine; flare; systemic lupus erythematosus; hydroxychloroquine; outcomes; response; kidney failure; lupus nephritis; antimalarial

Objectives To evaluate the effect of antimalarial drugs in response to therapy, incidence of LN flares, and progression of kidney disease in a large LN cohort. Methods We retrospectively studied 424 biopsy-proven LN patients followed for >3 years. We obtained demographic, clinical, laboratory, hi...