S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies

• Published in: Journal of Alzheimer's disease Vol. 64; no. 1; p. 171
• Main Authors: Leinonen, Ville, Rauramaa, Tuomas, Johansson, Jarkko, Bottelbergs, Astrid, Tesseur, Ina, van der Ark, Peter, Pemberton, Darrel, Koivisto, Anne M, Jääskeläinen, Juha E, Hiltunen, Mikko, Herukka, Sanna-Kaisa, Blennow, Kaj, Zetterberg, Henrik, Jokinen, Pekka, Rokka, Johanna, Helin, Semi, Haaparanta-Solin, Merja, Solin, Olof, Okamura, Nobuyuki, Kolb, Hartmuth C, Rinne, Juha O
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2018
• Subjects: amyloid-beta; Alzheimer’s disease; PIB; contstartabstract; tau; PTHK-5117; positron emission tomography; idiopathic normal pressure hydrocephalus; neuropathology

Detection of pathological tau aggregates could facilitate clinical diagnosis of Alzheimer's disease (AD) and monitor drug effects in clinical trials. S-[18F]THK-5117 could be a potential tracer to detect pathological tau deposits in brain. However, no previous study have correlated S-[18F]THK-5...