Type H vessels—a bridge connecting subchondral bone remodelling and articular cartilage degeneration in osteoarthritis development

• Published in: Rheumatology (Oxford, England) Vol. 62; no. 4; pp. 1436 - 1444
• Main Authors: Liu, Yuan, Xie, Hui-Qi, Shen, Bin
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 03.04.2023
• Subjects: Bone and Bones - pathology; Bone Remodeling; Cartilage, Articular - metabolism; Humans; Osteoarthritis, Knee - pathology; Osteogenesis; type H vessels; subchondral bone; TGF-β; knee osteoarthritis; PDGF-BB

Abstract Recent studies have shed light on the cellular and molecular mechanisms that link subchondral bone remodelling and angiogenesis in knee osteoarthritis (OA). Type H vessels are a newly identified bone blood vessel characterized by high expression of CD31 and endomucin that are coupled with o...