Application of Pharmacogenomics Testing in a Community-based Facility

• Published in: Hospital pharmacy (Philadelphia) Vol. 58; no. 1; pp. 98 - 105
• Main Authors: Wang, Jingyi, Paul, Sue, Arbet, Renee Noel, Lin, Alex C.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.02.2023
• Subjects: Original; psychiatric; clinical pathways; gene therapy
• DOI: 10.1177/00185787221134693
• ISSN: 0018-5787

This study was designed to examine the use of pharmacogenomics (PGx) testing in a community-based facility, the adoption of the PGx recommendations by providers, and assess challenges and opportunities for pharmacists in using PGx testing in a real-world setting. This was a retrospective study involving chart reviews of 137 patients with mood disorders who underwent PGx testing between September 2017 and December 2017. Eighty-seven patients who met inclusion and exclusion criteria were analyzed to evaluate the impact of PGx testing on psychotropic medication treatment and to evaluate the PGx test process. PGx test results were used by providers to guide their therapeutic modifications based on the gene-drug interactions identified. Patient medication use increased from 125 to 190 (P < .001) prescriptions. Patient medication belonging to no gene-drug interaction significantly increased from 46.4% to 87.4% (P < .001), medications belonging to moderate and significant gene-drug interaction decreased from 32.8% to 7.9% (P < .001) and 11.2% to 2.1% (P = .012), respectively. 88.5% of patients’ psychotropic medication treatment after PGx testing was consistent with the PGx test report recommendations. The PGx test lengths of time analysis indicated that patient follow-up exceeded the standard time set by guidelines at multiple steps in the test process. There are multiple opportunities for pharmacists to become involved in the PGx testing process to improve patient care.