In silico analysis and functional characterization of a leucine-rich repeat protein of Leptospira interrogans

• Published in: International journal of medical microbiology Vol. 316; p. 151633
• Main Authors: Gaspar, João P., Takahashi, Maria B., Teixeira, Aline F., Nascimento, Ana L.T.O.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.09.2024; Elsevier
• Subjects: Adhesin; Amino Acid Sequence; Animals; Bacterial Outer Membrane Proteins - chemistry; Bacterial Outer Membrane Proteins - genetics; Bacterial Outer Membrane Proteins - metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Circular Dichroism; Cloning, Molecular; Computer Simulation; Escherichia coli - genetics; Escherichia coli - metabolism; Host-pathogen interaction; Host-Pathogen Interactions; Humans; Leptospira; Leptospira interrogans - genetics; Leptospira interrogans - metabolism; Leptospirosis; Leptospirosis - microbiology; Leucine rich repeats; Leucine-Rich Repeat Proteins; Recombinant proteins; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Leptospirosis; Leucine rich repeats; Adhesin; Recombinant proteins; Host-pathogen interaction; Leptospira

Pathogenic spirochetes of the genus Leptospira are the causative agent of leptospirosis, a widely disseminated zoonosis that affects humans and animals. The ability of leptospires to quickly cross host barriers causing infection is not yet fully understood. Thus, understanding the mechanisms of path...