A Chewing Study of Abuse-Deterrent Tablets Containing Polyethylene Oxide Using a Robotic Simulator

• Published in: AAPS PharmSciTech Vol. 24; no. 8; p. 245
• Main Authors: Chen, Bangxiang, Zhang, Feng, Dhupia, Jaspreet, Morgenstern, Marco P., Costello, Mark, Boyce, Heather, Sun, Wei-Jhe, Raofi, Saeid, Tian, Li, Xu, Weiliang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 29.11.2023
• Subjects: Advancements in Modified-release Oral Drug Delivery - Delivery throughout the Gastro-intestinal Tract; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Delayed-Action Preparations; Humans; Mastication; Pharmacology/Toxicology; Pharmacy; Polyethylene Glycols; Research Article; Robotic Surgical Procedures; Tablets; abuse-deterrent formulation; physical barrier; manipulation; simulated chewing; opioids; in vitro manipulation

Abuse-deterrent formulations (ADFs) refer to formulation technologies aiming to deter the abuse of prescription drugs by making the dosage forms difficult to manipulate or extract the opioids. Assessments are required to evaluate the performance of the drugs through different routes including inject...