Carnosic Acid Reverses the Inhibition of ApoE4 on Cell Surface Level of ApoER2 and Reelin Signaling Pathway

• Published in: Journal of Alzheimer's disease Vol. 73; no. 2; p. 517
• Main Authors: Feng, Maoxiao, Cui, Donghai, Li, Yi, Shi, Jian, Xiang, Lan, Bian, Hong, Ma, Zhiyong, Xia, Wen, Wei, Guangwei
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2020
• Subjects: Apolipoprotein E receptor 2; Apolipoprotein E4; Reelin signaling pathway; sorting nexin 17; carnosic acid

The cell surface level of apolipoprotein E receptor 2 (ApoER2) increases by cyclic transport of ApoER2 and then activates Reelin signaling pathway to exert neuroprotective function in AD. ApoER2 ligand Apolipoprotein E4 (ApoE4) inhibits the recycling of ApoER2 to the cell surface rendering neurons u...