Evidence of increased oxidative damage in subjects with mild cognitive impairment

• Published in: Neurology Vol. 64; no. 7; p. 1152
• Main Authors: Keller, J N, Schmitt, F A, Scheff, S W, Ding, Q, Chen, Q, Butterfield, D A, Markesbery, W R
• Format: Journal Article
• Language: English
• Published: United States 12.04.2005
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Brain - metabolism; Brain - pathology; Brain - physiopathology; Cognition Disorders - metabolism; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Disease Progression; Female; Free Radicals - metabolism; Humans; Male; Malondialdehyde - metabolism; Memory Disorders - pathology; Memory Disorders - physiopathology; Memory Disorders - psychology; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; Neuropsychological Tests; Oxidative Stress - physiology; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Predictive Value of Tests; Protein Carbonylation - physiology; Thiobarbituric Acid Reactive Substances - metabolism; Up-Regulation - physiology
• ISSN: 1526-632X
• DOI: 10.1212/01.WNL.0000156156.13641.BA

To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondial...