The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 358; no. 2; pp. 262 - 270
• Main Authors: Ezzat, Shahira M., El Gaafary, Menna, El Sayed, Abeer M., Sabry, Omar M., Ali, Zeinab Y., Hafner, Susanne, Schmiech, Michael, Jin, Lu, Syrovets, Tatiana, Simmet, Thomas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016
• Subjects: Animals; Apocynaceae - chemistry; Biocatalysis; Biomarkers - blood; Cardenolides - chemistry; Cardenolides - isolation & purification; Cardenolides - pharmacology; Cardiotonic Agents - chemistry; Cardiotonic Agents - isolation & purification; Cardiotonic Agents - pharmacology; Cardiotoxicity - etiology; Cardiotoxicity - metabolism; Cardiotoxicity - pathology; Cardiotoxicity - prevention & control; DNA Topoisomerases, Type II - metabolism; Doxorubicin - adverse effects; Interferon Regulatory Factors - metabolism; Male; Mice; Mitochondrial Membranes - drug effects; Mitochondrial Membranes - enzymology; Models, Molecular; Molecular Conformation; Myocardium - metabolism; Myocardium - pathology; NF-kappa B - metabolism; Oxidative Stress - drug effects; Sodium-Potassium-Exchanging ATPase - metabolism; CRP; NO; AST; AKβBA; HMBC; CK-MB; AcoA; MDA; IL-6; IFN; LDH; NF-κB; RIG-1; NMR; TNF-α; bw; ROS; TAC; LD; cTn; IRF; GSH; ELISA

The current study aimed to investigate the protective effect of the cardenolide glycoside acovenoside A (AcoA) against doxorubicin-induced cardiotoxicity in mice. AcoA was isolated from the pericarps of Acokanthera oppositifolia to chemical homogeneity and characterized by means of one- and two-dime...