The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice - Ezzat, Shahira M.; El Gaafary, Menna; El Sayed, Abeer M.; Sabry, Omar M.; Ali, Zeinab Y.; Hafner, Susanne; Schmiech, Michael; Jin, Lu; Syrovets, Tatiana; Simmet, Thomas (The Journal of pharmacology and experimental therapeutics, 2016)
Keywords: Animals; Apocynaceae - chemistry; Biocatalysis; Biomarkers - blood; Cardenolides - chemistry; Cardenolides - isolation & purification; Cardenolides - pharmacology; Cardiotonic Agents - chemistry; Cardiotonic Agents - isolation & purification; Cardiotonic Agents - pharmacology; Cardiotoxicity - etiology; Cardiotoxicity - metabolism; Cardiotoxicity - pathology; Cardiotoxicity - prevention & control; DNA Topoisomerases, Type II - metabolism; Doxorubicin - adverse effects; Interferon Regulatory Factors - metabolism; Male; Mice; Mitochondrial Membranes - drug effects; Mitochondrial Membranes - enzymology; Models, Molecular; Molecular Conformation; Myocardium - metabolism; Myocardium - pathology; NF-kappa B - metabolism; Oxidative Stress - drug effects; Sodium-Potassium-Exchanging ATPase - metabolism; CRP; NO; AST; AKβBA; HMBC; CK-MB; AcoA; MDA; IL-6; IFN; LDH; NF-κB; RIG-1; NMR; TNF-α; bw; ROS; TAC; LD; cTn; IRF; GSH; ELISA