Augmentation Pressure Is Influenced by Ventricular Contractility/Relaxation Dynamics Novel Mechanism of Reduction of Pulse Pressure by Nitrates

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 63; no. 5; pp. 1050 - 1055
• Main Authors: Fok, Henry, Guilcher, Antoine, Li, Ye, Brett, Sally, Shah, Ajay, Clapp, Brian, Chowienczyk, Phil
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.05.2014
• Subjects: Adult; Aged; Arterial hypertension. Arterial hypotension; Arterial Pressure - drug effects; Arterial Pressure - physiology; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Blood Pressure - physiology; Cardiac Catheterization; Cardiology. Vascular system; Dose-Response Relationship, Drug; Female; Hemodynamics - drug effects; Hemodynamics - physiology; Humans; Male; Medical sciences; Middle Aged; Muscle Relaxation - drug effects; Muscle Relaxation - physiology; Myocardial Contraction - drug effects; Myocardial Contraction - physiology; Nitrates - pharmacology; Nitroglycerin - pharmacology; Pulse Wave Analysis; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Stroke Volume - drug effects; Stroke Volume - physiology; Ventricular Function - drug effects; Ventricular Function - physiology; Hypertension; Systolic pressure; Diastolic pressure; Contractility; Cardiovascular disease; Increase; Nitrates; Arterial pulse; Mechanism; Relaxation; Reduction; Dynamics; Analysis; pulse wave analysis; Arterial pressure; Hemodynamics; Circulatory system; Differential pressure

Augmentation pressure (AP), the increment in aortic pressure above its first systolic shoulder, is thought to be determined mainly by pressure wave reflection but could be influenced by ventricular ejection characteristics. We sought to determine the mechanism by which AP is selectively reduced by n...