Relevance of leukaemia inhibitory factor to anti-melanoma differentiation-associated gene 5 antibody-positive interstitial lung disease

• Published in: Rheumatology (Oxford, England) Vol. 62; no. 6; pp. 2267 - 2271
• Main Authors: Ichimura, Yuki, Ikei, Hiroyuki, Konishi, Risa, Zeniya, Moko, Okai, Takahiro, Nomura, Toshifumi, Negishi, Kousuke, Okiyama, Naoko
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2023
• Subjects: Aged; Amino Acyl-tRNA Synthetases; Autoantibodies; Dermatomyositis; Female; Humans; Interferon-Induced Helicase, IFIH1 - genetics; Leukemia Inhibitory Factor - genetics; Lung Diseases, Interstitial - etiology; Prognosis; Retrospective Studies; anti-melanoma differentiation-associated gene 5 antibody; leukaemia inhibitory factor; DM; transcriptome analysis

Abstract Objectives Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive rapidly progressive interstitial lung disease (RP-ILD) is a life-threatening disease, the aetiology of which remains unclear. To detect potential diagnostic markers, a transcriptome analysis of the lung samp...