Plasma Soluble ST2 Levels Are Higher in Neurodegenerative Disorders and Associated with Poorer Cognition

• Published in: Journal of Alzheimer's disease Vol. 92; no. 2; p. 573
• Main Authors: Tan, Yi Jayne, Siow, Isabel, Saffari, Seyed Ehsan, Ting, Simon K S, Li, Zeng, Kandiah, Nagaendran, Tan, Louis C S, Tan, Eng King, Ng, Adeline S L
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2023
• Subjects: Alzheimer Disease - psychology; Biomarkers - cerebrospinal fluid; Cognition; Cross-Sectional Studies; Frontotemporal Dementia - cerebrospinal fluid; Humans; Interleukin-1 Receptor-Like 1 Protein - metabolism; Interleukin-33 - metabolism; Parkinson Disease; ST2; neurodegeneration; dementia; Cognition; Parkinson’s disease

Suppressor of tumorgenicity 2 (ST2) is highly expressed in brain tissue and is a receptor for interleukin 33 (IL-33). ST2 exists in two forms, a transmembrane receptor (ST2L) and a soluble decoy receptor (sST2). IL-33 binds to ST2L, triggering downstream signaling pathways involved in amyloid plaque...