Antibacterial Activity of Some Medicinal Plants in Al Baha Region, Saudi Arabia, Against Carcinogenic Bacteria Related to Gastrointestinal Cancers

Background Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and induces the host’s susceptibility to carcinogenic bacteria. Antibiotic resistance is rising in these bacteria. Thus, discovering new safe and effec...

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Published inJournal of gastrointestinal cancer Vol. 54; no. 1; pp. 51 - 55
Main Authors Alzandi, Abdulrahman Ali, Taher, Essam Ahmed, Azizi, Mohamed, Al-Sagheer, Nageeb A., Al-Khulaidi, Abdul Wali, Naguib, Deyala M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2023
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacteria
Cancer Research
Carcinogenesis
Carcinogens
Ethanol
Gastroenterology
Gastrointestinal Neoplasms - drug therapy
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Research
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal
Radiotherapy
Saudi Arabia
Saudi Arabia
Gut microbiota
Pharmaceutical components
Antibiotic resistance
Minimum inhibitory concentration
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Abstract Background Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and induces the host’s susceptibility to carcinogenic bacteria. Antibiotic resistance is rising in these bacteria. Thus, discovering new safe and effective antibacterial agents is a worldwide concern. This study evaluates the antibacterial activity of six wild medicinal plants from the Al Bahah region in Saudi Arabia. Methods Arial parts of  Cissus quadrangularis , Aloe castellorum , Psiadia punctulata , Aloe pseudorubroviolacea , Barbeya oleoides ,  Teucrium yemense were collected and dried for extraction with ethanol. The minimum inhibitory concentrations (MIC) of these ethanolic extracts against carcinogenic bacteria Bacteroides fragilis, Clostridium ssp., Cutibacterium acnes, Escherichia coli, Fusobacterium nucleatum, Helicobacter pylori, Mycoplasma spp. , Neisseria gonorrhoeae, Porphyromonas gingivalis, Salmonella enterica, and Treponema pallidum were evaluated to determine its antibacterial activity. Results All extracts showed antibacterial activity with MIC lower than 1 mg/ml. Psiadia punctulata showed higher antibacterial activity, while the Aloe species showed the lowest antibacterial activity . Conclusion The studied plants ’ extracts showed high effectiveness as antibacterial activity against the carcinogenic bacteria related to gastrointestinal cancers due to their high content of pharmaceutical components. These plants could be explored further for the development of new antibacterial products against these carcinogenic bacteria.
AbstractList Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and induces the host's susceptibility to carcinogenic bacteria. Antibiotic resistance is rising in these bacteria. Thus, discovering new safe and effective antibacterial agents is a worldwide concern. This study evaluates the antibacterial activity of six wild medicinal plants from the Al Bahah region in Saudi Arabia. Arial parts of Cissus quadrangularis, Aloe castellorum, Psiadia punctulata, Aloe pseudorubroviolacea, Barbeya oleoides, Teucrium yemense were collected and dried for extraction with ethanol. The minimum inhibitory concentrations (MIC) of these ethanolic extracts against carcinogenic bacteria Bacteroides fragilis, Clostridium ssp., Cutibacterium acnes, Escherichia coli, Fusobacterium nucleatum, Helicobacter pylori, Mycoplasma spp., Neisseria gonorrhoeae, Porphyromonas gingivalis, Salmonella enterica, and Treponema pallidum were evaluated to determine its antibacterial activity. All extracts showed antibacterial activity with MIC lower than 1 mg/ml. Psiadia punctulata showed higher antibacterial activity, while the Aloe species showed the lowest antibacterial activity. The studied plants' extracts showed high effectiveness as antibacterial activity against the carcinogenic bacteria related to gastrointestinal cancers due to their high content of pharmaceutical components. These plants could be explored further for the development of new antibacterial products against these carcinogenic bacteria.
Background Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and induces the host’s susceptibility to carcinogenic bacteria. Antibiotic resistance is rising in these bacteria. Thus, discovering new safe and effective antibacterial agents is a worldwide concern. This study evaluates the antibacterial activity of six wild medicinal plants from the Al Bahah region in Saudi Arabia. Methods Arial parts of  Cissus quadrangularis , Aloe castellorum , Psiadia punctulata , Aloe pseudorubroviolacea , Barbeya oleoides ,  Teucrium yemense were collected and dried for extraction with ethanol. The minimum inhibitory concentrations (MIC) of these ethanolic extracts against carcinogenic bacteria Bacteroides fragilis, Clostridium ssp., Cutibacterium acnes, Escherichia coli, Fusobacterium nucleatum, Helicobacter pylori, Mycoplasma spp. , Neisseria gonorrhoeae, Porphyromonas gingivalis, Salmonella enterica, and Treponema pallidum were evaluated to determine its antibacterial activity. Results All extracts showed antibacterial activity with MIC lower than 1 mg/ml. Psiadia punctulata showed higher antibacterial activity, while the Aloe species showed the lowest antibacterial activity . Conclusion The studied plants ’ extracts showed high effectiveness as antibacterial activity against the carcinogenic bacteria related to gastrointestinal cancers due to their high content of pharmaceutical components. These plants could be explored further for the development of new antibacterial products against these carcinogenic bacteria.
Author Al-Sagheer, Nageeb A.
Alzandi, Abdulrahman Ali
Azizi, Mohamed
Al-Khulaidi, Abdul Wali
Naguib, Deyala M.
Taher, Essam Ahmed
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Keywords Gut microbiota
Pharmaceutical components
Antibiotic resistance
Minimum inhibitory concentration
Language English
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Snippet Background Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and...
Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and induces the...
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pubmed
springer
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StartPage 51
SubjectTerms Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacteria
Cancer Research
Carcinogenesis
Carcinogens
Ethanol
Gastroenterology
Gastrointestinal Neoplasms - drug therapy
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Research
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal
Radiotherapy
Saudi Arabia
Title Antibacterial Activity of Some Medicinal Plants in Al Baha Region, Saudi Arabia, Against Carcinogenic Bacteria Related to Gastrointestinal Cancers
URI https://link.springer.com/article/10.1007/s12029-021-00793-w
https://www.ncbi.nlm.nih.gov/pubmed/34988907
Volume 54
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