Early Detection of Learning Difficulties when Confronted with Novel Information in Preclinical Alzheimer's Disease Stage 1

• Published in: Journal of Alzheimer's disease Vol. 58; no. 3; p. 855
• Main Authors: Tort-Merino, Adrià, Valech, Natalia, Peñaloza, Claudia, Grönholm-Nyman, Petra, León, María, Olives, Jaume, Estanga, Ainara, Ecay-Torres, Mirian, Fortea, Juan, Martínez-Lage, Pablo, Molinuevo, José L, Laine, Matti, Rodríguez-Fornells, Antoni, Rami, Lorena
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2017
• Subjects: Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - complications; Alzheimer Disease - diagnosis; Alzheimer Disease - psychology; Amyloid beta-Peptides - cerebrospinal fluid; Apolipoproteins E - genetics; Biomarkers - cerebrospinal fluid; Disease Progression; Early Diagnosis; Female; Humans; Learning; Learning Disorders - cerebrospinal fluid; Learning Disorders - diagnosis; Learning Disorders - etiology; Longitudinal Studies; Male; Memory; Middle Aged; Multivariate Analysis; Neuropsychological Tests; Peptide Fragments - cerebrospinal fluid; Prodromal Symptoms; Severity of Illness Index; tau Proteins - cerebrospinal fluid; neuropsychology; memory; Alzheimer’s disease; biomarkers; cognitive aging
• ISSN: 1875-8908
• DOI: 10.3233/JAD-161173

We employed a highly demanding experimental associative learning test (the AFE-T) to explore memory functioning in Preclinical Alzheimer's Disease stage 1 (PreAD-1) and stage 2 (PreAD-2). The task consisted in the learning of unknown object/name pairs and our comprehensive setup allowed the ana...