Aromaticity in catalysis: metal ligand cooperation via ligand dearomatization and rearomatization

Unlike the conventional model of transition metal catalysis, ligands in metal-ligand cooperative (or bifunctional) catalysis are involved in the substrate activations. Such processes have offered unique mechanistic understandings and led to new concepts for the catalyst design. In particular, unprec...

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Published inChemical communications (Cambridge, England) Vol. 57; no. 25; pp. 3070 - 3082
Main Authors Gonçalves, Théo P, Dutta, Indranil, Huang, Kuo-Wei
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 28.03.2021
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Abstract Unlike the conventional model of transition metal catalysis, ligands in metal-ligand cooperative (or bifunctional) catalysis are involved in the substrate activations. Such processes have offered unique mechanistic understandings and led to new concepts for the catalyst design. In particular, unprecedented activities were discovered when the ligand could undergo dearomatization-rearomatization reactions during the catalytic cycle. Aromatization can provide an extra driving force to thermodynamics; consequently, it brings a new perspective to ligand platform design for catalysis. While numerous applications were demonstrated, the influences of changing ligand aromatic properties were often overlooked. In this article, representative ligand systems will be highlighted and a comparison between the Milstein and the Huang pincer systems will be discussed to provide theoretical and conceptual insights.
AbstractList Unlike the conventional model of transition metal catalysis, ligands in metal–ligand cooperative (or bifunctional) catalysis are involved in the substrate activations. Such processes have offered unique mechanistic understandings and led to new concepts for the catalyst design. In particular, unprecedented activities were discovered when the ligand could undergo dearomatization–rearomatization reactions during the catalytic cycle. Aromatization can provide an extra driving force to thermodynamics; consequently, it brings a new perspective to ligand platform design for catalysis. While numerous applications were demonstrated, the influences of changing ligand aromatic properties were often overlooked. In this article, representative ligand systems will be highlighted and a comparison between the Milstein and the Huang pincer systems will be discussed to provide theoretical and conceptual insights.
Author Gonçalves, Théo P
Huang, Kuo-Wei
Dutta, Indranil
Author_xml – sequence: 1
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  surname: Gonçalves
  fullname: Gonçalves, Théo P
  email: hkw@kaust.edu.sa
  organization: KAUST Catalysis Center and Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. hkw@kaust.edu.sa
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  givenname: Indranil
  surname: Dutta
  fullname: Dutta, Indranil
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  givenname: Kuo-Wei
  surname: Huang
  fullname: Huang, Kuo-Wei
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33656025$$D View this record in MEDLINE/PubMed
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Snippet Unlike the conventional model of transition metal catalysis, ligands in metal-ligand cooperative (or bifunctional) catalysis are involved in the substrate...
Unlike the conventional model of transition metal catalysis, ligands in metal–ligand cooperative (or bifunctional) catalysis are involved in the substrate...
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SubjectTerms Aromaticity
Catalysis
Ligands
Substrates
Transition metals
Title Aromaticity in catalysis: metal ligand cooperation via ligand dearomatization and rearomatization
URI https://www.ncbi.nlm.nih.gov/pubmed/33656025
https://www.proquest.com/docview/2504770096/abstract/
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