Thermosensitive liposomes containing cisplatin functionalized by hyaluronic acid: preparation and physicochemical characterization

• Published in: Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology Vol. 24; no. 2
• Main Authors: Gomes, Isabela P., Malachias, Ângelo, Maia, Ana Luiza Chaves, Lages, Eduardo B., Ferreira, Felipe Alves, Alves, Ricardo J., Giuberti, Cristiane S., de Barros, Andre Luis B., Leite, Elaine A.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2022; Springer Nature B.V
• Subjects: Characterization and Evaluation of Materials; Chemistry and Materials Science; Chemotherapy; Cisplatin; Diffusion rate; Hyaluronic acid; Inorganic Chemistry; Lasers; Light scattering; Lipids; Liposomes; Materials Science; Misalignment; Nanoparticles; Nanotechnology; Optical Devices; Optics; Phospholipids; Photon correlation spectroscopy; Photonics; Physical Chemistry; Polymers; Research Paper; Small angle X ray scattering; X-ray scattering; Zeta potential; Characterization; Lipid bilayer; Hyaluronic acid; Thermosensitive liposome

This study aimed to develop a thermosensitive liposomal formulation (TSL) functionalized with hyaluronic acid (HA), to encapsulate a hydrophilic drug, the cisplatin (CDDP). The physicochemical and thermal characteristics of this new formulation were studied by dynamic light scattering (DLS), microca...