Estrogen receptor beta (ESR2) gene polymorphism and susceptibility to dementia

• Published in: Acta neurologica Belgica Vol. 121; no. 5; pp. 1281 - 1293
• Main Authors: Ulhaq, Zulvikar Syambani, Garcia, Cristian Peinado
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2021
• Subjects: Alleles; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Dementia - genetics; Estrogen Receptor alpha - genetics; Estrogen Receptor beta - genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Medicine/Public Health; Neurology; Neuroradiology; Neurosciences; Original Article; Polymorphism, Single Nucleotide; Alzheimer’s disease; Polymorphisms; Estrogen receptor beta; Cognitive impairment; Dementia; ESR2

Strong evidence supports the involvement of sex steroid hormones in the development and progression of dementia. Attention has been largely focused on the association between genetic variants of estrogen receptor alpha (ERα , ESR1 ) with dementia, although several studies indicate that ERβ is predom...