Etanercept Ameliorates Vascular, Endocrine, and Ovarian Changes in a Rat Model of DHEA-Induced Polycystic Ovary Syndrome

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Vol. 31; no. 3; pp. 714 - 726
• Main Authors: Utkan Korun, Zeynep Ece, Gocmez, Semil Selcen, Furat Rencber, Selenay, Kavram Sarıhan, Kübra, Eraldemir, Fatma Ceylan, Sahin, Deniz
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2024
• Subjects: Embryology; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Reproductive Biology: Original Article; Reproductive Medicine; Thoracic aorta; PCOS; Inflammation; Etanercept; TNF-α; Vascular function

Polycystic ovary syndrome (PCOS) is a metabolic and endocrine disorder affecting women of reproductive age. This study examined the efficacy of etanercept (ETA), an anti-TNF-α drug, in alleviating endocrine, metabolic, and vascular dysfunction in a rat model of PCOS. Prepubertal female Wistar rats w...