Current Progress on Esterases: From Molecular Structure to Function

• Published in: Drug metabolism and disposition Vol. 30; no. 5; pp. 488 - 493
• Main Authors: SATOH, Tetsuo, TAYLOR, Palmer, BOSRON, William F, SANGHANI, Sonal P, HOSOKAWA, Masakiyo, LA DU, Bert N
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.05.2002
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Enzymes and enzyme inhibitors; Esterases - chemistry; Esterases - genetics; Esterases - physiology; Evolution, Molecular; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Humans; Hydrolases; Organ Specificity; Pharmaceutical Preparations - metabolism; Protein Folding; Substrate Specificity; Congress; Cell function; Enzymatic activity; Molecular structure; Enzyme; Hydrolases; Esterases; Review; Gene expression; Mechanism of action
• ISSN: 0090-9556; 1521-009X
• DOI: 10.1124/dmd.30.5.488

This article reports on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. Current developments in molecular-based studies into the structure and function of cholinesterases, carboxylesterases, and paraoxonases are described. This article covers mechanisms of regulation of gene expression of the various esterases by developmental factors and xenobiotics, as well as the interplay between physiological and chemical regulation of enzyme activity.