Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

• Published in: Current obesity reports Vol. 8; no. 3; pp. 317 - 332
• Main Authors: Vallianou, Natalia, Stratigou, Theodora, Christodoulatos, Gerasimos Socrates, Dalamaga, Maria
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2019
• Subjects: Animals; Behavioral Therapy; Butyrates - metabolism; Butyrates - pharmacology; Cardiology; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - prevention & control; Dysbiosis - complications; Endocrinology; Gastrointestinal Microbiome - physiology; Humans; Intestines - microbiology; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic Diseases - complications; Metabolic Diseases - metabolism; Metabolic Diseases - prevention & control; Metabolic Diseases - therapy; Metabolic Syndrome - complications; Metabolism (M Dalamaga; Metabolome - physiology; Non-alcoholic Fatty Liver Disease - complications; Obesity - complications; Obesity - metabolism; Obesity - prevention & control; Obesity - therapy; Polysaccharides - metabolism; Prebiotics; Section Editor; Synbiotics; Topical Collection on Metabolism; Obesity; Metabolite; Gut; Metabolic syndrome; Synbiotics; Prebiotics; Probiotics; Metabolic disorder; Microbiota; Intestine; Diabetes; Non-alcoholic fatty liver disease; Microbiome

Purpose In this review, we summarize current evidence on the gut microbiome and microbial metabolites in relation to obesity and obesity-associated metabolic disorders. Special emphasis is given on mechanisms interconnecting gut microbiome and microbial metabolites with metabolic disorders as well a...