Review of Approaches for Increasing Ophthalmic Bioavailability for Eye Drop Formulations

• Published in: AAPS PharmSciTech Vol. 22; no. 3; p. 107
• Main Authors: Lanier, Olivia L., Manfre, Miranda G., Bailey, Claire, Liu, Zhen, Sparks, Zachary, Kulkarni, Sandesh, Chauhan, Anuj
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 14.03.2021
• Subjects: Administration, Ophthalmic; Animals; Biochemistry; Biological Availability; Biomedical and Life Sciences; Biomedicine; Biotechnology; Cornea - drug effects; Cornea - metabolism; Drug Compounding - methods; Drug Delivery Systems - methods; Eye Diseases - drug therapy; Eye Diseases - metabolism; Humans; Ophthalmic Solutions - administration & dosage; Ophthalmic Solutions - chemical synthesis; Ophthalmic Solutions - pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Prodrugs - administration & dosage; Prodrugs - chemical synthesis; Prodrugs - pharmacokinetics; Review Article; Theme: Ocular Drug Delivery and Ophthalmic Formulations; Viscosity; eye drops; nanoparticles; drug delivery; permeability enhancers; bioavailability

Ophthalmic diseases represent a significant problem as over 2 billion people worldwide suffer from vison impairment and blindness. Eye drops account for around 90% of ophthalmic medications but are limited in success due to poor patient compliance and low bioavailability. Low bioavailability can be...