Flavonols Protect Against UV Radiation-Induced Thymine Dimer Formation in an Artificial Skin Mimic

• Published in: Journal of pharmacy & pharmaceutical sciences Vol. 18; no. 4; pp. 600 - 615
• Main Authors: Maini, Sabia, Fahlman, Brian M, Krol, Ed S
• Format: Journal Article
• Language: English
• Published: Canada Frontiers Media S.A 01.01.2015
• Subjects: Administration, Cutaneous; Cell Line; Chromatography, High Pressure Liquid - methods; Flavonoids - administration & dosage; Flavonoids - pharmacology; Flavonols - administration & dosage; Flavonols - pharmacology; Humans; Kaempferols - administration & dosage; Kaempferols - pharmacology; Keratinocytes - drug effects; Keratinocytes - metabolism; Keratinocytes - radiation effects; Matrix Metalloproteinase 1 - metabolism; Pilot Projects; Pyrimidine Dimers - metabolism; Quercetin - administration & dosage; Quercetin - pharmacology; Skin - drug effects; Skin - metabolism; Skin - radiation effects; Tandem Mass Spectrometry - methods; Tumor Necrosis Factor-alpha - metabolism; Ultraviolet Rays - adverse effects

Exposure of skin to ultraviolet light has been shown to have a number of deleterious effects including photoaging, photoimmunosuppression and photoinduced DNA damage which can lead to the development of skin cancer. In this paper we present a study on the ability of three flavonols to protect EpiDer...