Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy

• Published in: Neurology Vol. 68; no. 24; p. 2113
• Main Authors: Zhou, L, Kitch, D W, Evans, S R, Hauer, P, Raman, S, Ebenezer, G J, Gerschenson, M, Marra, C M, Valcour, V, Diaz-Arrastia, R, Goodkin, K, Millar, L, Shriver, S, Asmuth, D M, Clifford, D B, Simpson, D M, McArthur, J C
• Format: Journal Article
• Language: English
• Published: United States 12.06.2007
• Subjects: Action Potentials - physiology; Adult; Aged; Female; HIV Infections - complications; Humans; Male; Middle Aged; Nerve Fibers - pathology; Nerve Fibers - virology; Neural Conduction - physiology; Neuralgia - pathology; Neuralgia - physiopathology; Neuralgia - virology; Pain Measurement; Peripheral Nerves - pathology; Peripheral Nerves - physiopathology; Peripheral Nerves - virology; Peripheral Nervous System Diseases - pathology; Peripheral Nervous System Diseases - physiopathology; Peripheral Nervous System Diseases - virology; Phenotype; Prospective Studies; Sensory Receptor Cells - pathology; Sensory Receptor Cells - physiopathology; Sensory Receptor Cells - virology; Skin - innervation; Skin - pathology; Skin - physiopathology; Sural Nerve - pathology; Sural Nerve - physiopathology; Sural Nerve - virology

To demonstrate the relationship between epidermal nerve fiber density (ENFD) in the leg and the phenotype of HIV-associated distal sensory polyneuropathy (HIV-DSP) in a multicenter prospective study (ACTG A5117). A total of 101 HIV-infected adults, with CD4 cell count <300 cells/mm(3) and who had...