Pentylenetetrazole-induced changes in cerebral energy metabolism in Tupaia glis

• Published in: Epilepsia (Copenhagen) Vol. 28; no. 2; p. 184
• Main Authors: McCandless, D W, Dworsky, S, Modak, A T, Stavinoha, W B
• Format: Journal Article
• Language: English
• Published: United States 01.03.1987
• Subjects: Adenosine Triphosphate - metabolism; Animals; Brain - metabolism; Cerebellum - metabolism; Cerebral Cortex - metabolism; Energy Metabolism - drug effects; Female; Glucose - metabolism; Glycogen - metabolism; Pentylenetetrazole - pharmacology; Phosphocreatine - metabolism; Seizures - chemically induced; Seizures - metabolism; Tupaia - metabolism; Tupaiidae - metabolism

The convulsant pentylenetetrazole was administered to the lower primate, the tree shrew. Shortly after the onset of seizures, the animals were killed using a microwave device at 25 Kw and 915 MHz. The energy metabolites glycogen, glucose, ATP, and phosphocreatine were measured in five layers of the...