Retinal Nerve Fiber Layer Thickness Measurement Comparison Using Spectral Domain and Swept Source Optical Coherence Tomography

• Published in: Korean journal of ophthalmology Vol. 30; no. 2; pp. 140 - 147
• Main Authors: Ha, Ahnul, Lee, Seung Hyen, Lee, Eun Ji, Kim, Tae-Woo
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Ophthalmological Society 01.04.2016; 대한안과학회
• Subjects: Aged; False Positive Reactions; Female; Glaucoma, Open-Angle - diagnosis; Humans; Intraocular Pressure - physiology; Male; Middle Aged; Nerve Fibers - pathology; Optic Disk - pathology; Optic Nerve Diseases - diagnosis; Original; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Retinal Ganglion Cells - pathology; ROC Curve; Tomography, Optical Coherence - methods; Tonometry, Ocular; Visual Acuity - physiology; 안과학; Glaucoma; Diagnostic capability; Optical coherence tomography; Retinal nerve fiber layer thicknesses
• ISSN: 1011-8942; 2092-9382; 2092-9382
• DOI: 10.3341/kjo.2016.30.2.140

To investigate the retinal nerve fiber layer (RNFL) thickness concordance when measured by spectral domain (SD) and swept source (SS) optical coherence tomography (OCT), and to compare glaucoma-discriminating capability. RNFL thicknesses were measured with the scan circle, centered on the optic nerve head, in 55 healthy, 41 glaucoma suspected, and 87 glaucomatous eyes. The RNFL thickness measured by the SD-OCT (sdRNFL thickness) and SS-OCT (ssRNFL thickness) were compared using the t-test. Bland-Altman analysis was performed to examine their agreement. We compared areas under the receiver operating characteristics curve and examined sdRNFL and ssRNFL thickness for discriminating glaucomatous eyes from healthy eyes, and from glaucoma suspect eyes. The average ssRNFL thickness was significantly greater than sdRNFL thickness in healthy (110.0 ± 7.9 vs. 100.1 ± 6.8 µm, p < 0.001), glaucoma suspect (96.8 ± 9.3 vs. 89.6 ± 7.9 µm, p < 0.001), and glaucomatous eyes (74.3 ± 14.2 vs. 69.1 ± 12.4 µm, p = 0.011). Bland-Altman analysis showed that there was a tendency for the difference between ssRNFL and sdRNFL to increase in eyes with thicker RNFL. The area under the curves of the average sdRNFL and ssRNFL thickness for discriminating glaucomatous eyes from healthy eyes (0.984 vs. 0.986, p = 0.491) and glaucoma suspect eyes (0.936 vs. 0.918, p = 0.132) were comparable. There was a tendency for ssRNFL thickness to increase, compared with sdRNFL thickness, in eyes with thicker RNFL. The ssRNFL thickness had comparable diagnostic capability compared with sdRNFL thickness for discriminating glaucomatous eyes from healthy eyes and glaucoma suspect eyes.