Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression

• Published in: Journal of virology Vol. 91; no. 6
• Main Authors: Jacobs, Evan S., Keating, Sheila M., Abdel-Mohsen, Mohamed, Gibb, Stuart L., Heitman, John W., Inglis, Heather C., Martin, Jeffrey N., Zhang, Jinbing, Kaidarova, Zhanna, Deng, Xutao, Wu, Shiquan, Anastos, Kathryn, Crystal, Howard, Villacres, Maria C., Young, Mary, Greenblatt, Ruth M., Landay, Alan L., Gange, Stephen J., Deeks, Steven G., Golub, Elizabeth T., Pillai, Satish K., Norris, Philip J.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.03.2017
• Subjects: Adult; Antigens, Differentiation - biosynthesis; CD4-Positive T-Lymphocytes - virology; Cytokines - metabolism; Female; Gene Expression Regulation; HIV - immunology; HIV - physiology; HIV Infections - immunology; HIV Long-Term Survivors; Humans; Membrane Proteins - biosynthesis; Middle Aged; Pathogenesis and Immunity; Plasma - chemistry; Receptors, HIV - biosynthesis; Virus Replication - drug effects; restriction factor; chemokine receptors; cytokines; HIV; elite control

A subset of HIV-infected individuals termed elite controllers (ECs) maintain CD4 + T cell counts and control viral replication in the absence of antiretroviral therapy (ART). Systemic cytokine responses may differentiate ECs from subjects with uncontrolled viral replication or from those who require...