Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion

• Published in: Journal of vascular surgery Vol. 41; no. 1; pp. 99 - 107
• Main Authors: Casey, Patrick J., Black, James H., Szabo, Csaba, Frosch, Matthew, Albadawi, Hassan, Chen, Min, Cambria, Richard P., Watkins, Michael T.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 2005; Elsevier
• Subjects: Animals; Aorta, Abdominal; Aorta, Thoracic; Bacterial diseases; Bacterial endocarditis, myocarditis and pericarditis. Bacterial diseases of the aorta, limb vessels and lymphatic vessels; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the aorta; Human bacterial diseases; Immunohistochemistry; Infectious diseases; Injections, Intraperitoneal; Male; Medical sciences; Mice; Motor Neurons - pathology; Phenanthrenes - administration & dosage; Phenanthrenes - pharmacology; Phenanthrenes - therapeutic use; Poly Adenosine Diphosphate Ribose - metabolism; Poly(ADP-ribose) Polymerase Inhibitors; Protozoan Proteins; Reperfusion Injury - prevention & control; Spinal Cord - drug effects; Spinal Cord - pathology; Spinal Cord - physiopathology; Spinal Cord Diseases - etiology; Spinal Cord Diseases - physiopathology; Spinal Cord Diseases - prevention & control; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels; Adenosine; Spinal cord; Ischemia; Surgery; Aorta; Cardiovascular disease; Thoracoabdominal

Spinal cord injury (SCI) remains a source of morbidity after thoracoabdominal aortic reconstruction. These studies were designed to determine whether PJ34, a novel ultrapotent inhibitor of the nuclear enzyme poly(adenosine diphosphate ribose) polymerase (PARP) could modulate neurologic injury after...