The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant

• Published in: Glycobiology (Oxford) Vol. 34; no. 2
• Main Authors: Pegg, Cassandra L, Modhiran, Naphak, Parry, Rhys H, Liang, Benjamin, Amarilla, Alberto A, Khromykh, Alexander A, Burr, Lucy, Young, Paul R, Chappell, Keith, Schulz, Benjamin L, Watterson, Daniel
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 26.03.2024
• Subjects: Antibodies, Viral; COVID-19; Editor's Choice; Glycosylation; Humans; Original; SARS-CoV-2; Spike Glycoprotein, Coronavirus; glycoproteomics; coronavirus; mass spectrometry; antibodies; glycoprotein

The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity towards the viral spike protein, whether acquired from infection or vaccination. Mutations that impact N-glycosylation of spike may be particularly important in influencing antigenicity, but their consequences are difficul...